P-010 The impact of COVID-19 Vaccination on Sperm Parameters in Indian Men: A Comparative Study

Abstract Study question To analyse the effect of COVID-19 vaccines on sperm parameters in Indian men seeking infertility treatment. Summary answer vaccination did not impact undergoing treatment this study. What is known already The pandemic triggered an expedited response from scientific community to develop preventive vaccine programs against deadly SARS-CoV-2 virus. Although predominantly a respiratory system illness, initial reports suggested that it could have short-term negative males affected by disease too. Misinformation led unfounded concerns about potential consequences male fertility, causing great deal hesitancy. address these concerns, we compared before and after COVID available India at time design, size, duration It was multi-centre, prospective, observational study 960 participants conducted our fertility clinics between June 2021 December 2022. were matched for age had no risk factors. We excluded 267 since they meet inclusion criteria, bringing total population down 693. Participants/materials, setting, methods provided two semen samples analysis receiving any A trained embryologist analysed pre-vaccination post-vaccination concentration motility males, following 6th Edition WHO Manual Semen Analysis. GraphPad Prism 9 used statistical data & p ≤ 0.05 considered statistically significant. Main results role chance enrolled 693 people, with 96.5% least one dose 90.35% or more. most common among group made-Covishield Covaxin, received 71.8% 24.3% participants, respectively. In who tested positive (n = 259), increased 3.29 million/ml 3.24% post-vaccination. However, changes significant (p 0.140 0.099, respectively). 424), observed similar increase 1.52 0.85%. also 0.580 0.404, Subgroup different reveal differences either. conclusion, found vaccination, including type used, significantly men. Limitations, reasons caution Supply chain disruptions program meant match analyses Additionally, findings are specific may be generalizable other populations settings. Wider implications This affect chances fatherhood. Our work supports safety Indian-made treatment, as extensive studies area. Trial registration number Not Applicable